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Associate Director, Computational Biology at Beeline Medicines. . Location: United States. About Beeline Medicines:. . Beeline Medicines is a clinical‑stage biotechnology company focused on developing and delivering category-leading precision therapies to transform the lives of people living with autoimmune and inflammatory diseases. With a portfolio of potential best-in-class and first-in-disease therapeutic candidates that directly target key pathways governing dysregulated immunological and inflammatory responses, the Company is developing medicines that have the opportunity to provide durable, life-changing impact. Led by an established executive team and backed by world-class life science investors, each day Beeline Medicines is determined to bring the scientific rigor and operational excellence to get to what matters for patients – realizing a world where people with immune-mediated diseases can live life fully.. Job Summary:. . The Associate Director of Computational Biology applies advanced computational, statistical, and machine learning approaches to accelerate therapeutic discovery and development. This role integrates deep biological insight with high dimensional data analytics to identify pharmacodynamic, mechanistic drivers of disease and response enrichment biomarkers. The Associate Director partners closely with pharmacokinetics, statistics, clinical, and external collaborators to deliver rigorous and actionable scientific insights that shape portfolio strategy.. . Work Arrangement & Location: . . Remote - . This position is designated as remote; the incumbent will be expected to travel to Beeline Medicines’ offices on a periodic basis to support in-person collaboration, team engagement, and business operations. The frequency and scheduling of such visits will be determined at the company's discretion based on business need.. . Essential Duties and Responsibilities: . . . Design, implement, and oversee multi omics analyses (transcriptomics, proteomics, genomics, single cell, spatial, etc.) to uncover disease mechanisms and therapeutic opportunities.. . Develop and apply advanced modeling approaches, including graph machine learning, network analysis, and causal inference frameworks.. . Integrate patient derived datasets, in vitro human centric model data, and real world evidence to drive translational insights.. . Identify and validate therapeutic targets, biomarkers, and mechanistic hypotheses that inform discovery and early development programs.. . Partner with experimental teams to design studies, interpret results, and refine hypotheses.. . Contribute to scientific strategy, portfolio prioritization, and data driven decision making across programs.. . Collaborate with pharmacokinetics, statistics, biology, and clinical teams to ensure cohesive scientific execution of the translational strategies.. . Support external partnerships by aligning deliverables, managing stakeholder expectations, and ensuring high quality scientific outputs.. . Communicate complex computational findings to diverse audiences, including executives, partners, and non computational scientists. .. . Perform other duties and responsibilities as assigned. . . Qualifications:. . . Education: PhD in computational biology, bioinformatics, systems biology, genomics, or a closely related quantitative life sciences discipline required.. . Minimum of 7 years of experience in biotech/pharma or translational research, with a strong track record of scientific impact.. . Demonstrated expertise in high dimensional biological data analysis and modern computational methods (e.g., ML/AI, network biology, multi omics integration).. . Strong biological background and ability to translate computational findings into mechanistic hypotheses.. . Demonstrated experience with machine learning and statistical modeling approaches applied to biological data, including dimensionality reduction, clustering, classification, and predictive modeling.. . Scientific expertise in immunology, autoimmunity, or inflammation biology is highly desirable; prior experience in lupus or related autoimmune indications is a strong advantage.. . Experience with patient stratification, biomarker discovery, or predictive modeling approaches applied to clinical trial datasets.. . Familiarity with databases and platforms relevant to drug discovery and translational research, including GTEx, ENCODE, GWAS data, GEO, and disease-specific consortia datasets.. . Demonstrated ability to lead, mentor, and develop cross-functional teams in a fast-paced, resource-constrained biotech or pharmaceutical environment; fosters a culture of accountability, inclusion, and continuous learning.. . Exceptional written and verbal communication skills with demonstrated ability to translate complex scientific, regulatory, or operational content for diverse audiences, including executive leadership, clinical teams, and external partners.. . Adept at facilitating productive dialogue in high-stakes meetings, negotiations, and multi-party collaborations; balances clarity, diplomacy, and scientific precision.. . This position must be able to work East Coast hours.. . Salary Range:. . The expected annual salary range for this position is listed below. Actual pay will be determined based on experience, qualifications, location, and other job-related factors permitted by law. A discretionary annual bonus and long-term incentive award (e.g., equity) may be available based on individual and Company performance.. Salary Range. $217,000. - . $231,000. . USD. Benefits:. . We offer a comprehensive benefits package including:. . . Medical, Dental & Vision insurance (employee premiums 100% covered by company). . 20 accrued days combined time off (PTO/Sick), 12 company holidays, & winter recharge. . Flexible work arrangements / hybrid schedule. . Health Savings Account (HSA). . . *Benefits are subject to eligibility requirements and plan terms. Additional details provided during the offer process*. . Equal Employment Opportunity:. . Beeline Medicines is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity or expression, national origin, disability, age, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.. . Reasonable Accommodation:. . If you require a reasonable accommodation to participate in the application or interview process, please contact [email protected] to request an accommodation. We are committed to providing equal access to all candidates.. . Privacy. Upon submission of this form I understand that Beeline Medicines is based in the United States and personal data submitted in the form will be transferred and accessed in the U.S., Information about Beeline Medicines privacy practices can be found at . Privacy Policy - Beeline Medicines